Q1)a) Give the chemical formula for this compound.

C5H9N3

 

b) Circle the amine functional groups in histamine

NH2, N and HN

 

c) Which part (or parts) of the molecule make the compound water soluble. 

The “salt” end.

 

2) a) Give the chemical formula for this compound

C16H21N3

 

b) What similarities do you see between this structure and that of histamine that would allow the antihistamine to compete with histamine

They share a sequence of N-C-N atoms and a 2 Carbon chain with Nitrogen at the end. Another similarity is how these sequences are placed. Also, the antihistamine has a flat 6-ring, similar to the flat 5-ring of histamine.

The antihistamine would block histamine action by binding more tightly to histamine receptor sites on cells than histamine.

 

3)

• Aspirin – Physiological Response
• Morphine – Physiological Response
• Antibiotic – Inhibit the Growth of Substances
• Estrogen – Physiological Response
• Amphetamine – Inhibit the Growth of Substances
• Penicillin – Inhibit the Growth of Substances

 

4) a) What do you think is the evidence from herbal supplement manufacturers that address these issues?

 

There are dietary supplement labels the contents and ingredients, and the amount of each inside every supplement. Also, you are advised to listen to your health care provider (e.g. doctor) to decide what amount of supplement you should be taking, instead of jut following the suggesting serving size.

 

b) Do you know anything about Singapore’s legislation on the topic?

From the Ministry of Health: https://www.moh.gov.sg/content/moh_web/healthprofessionalsportal/tcmpractitioners.html

The Health Sciences Authority (HSA) regulates all Chinese Proprietary Medicines in the tablet, capsule, etc. form. Before they can be sold in Singapore, they must comply with quality and safety criteria. HSA will also license dealers of these products.