Meeting Log 4 (29th March 2017)

Location: LHS TR-10

Time: 1330-1600

Duration: 2hrs 30mins

Attendance

Present:

  1. Akshaya
  2. Amanda
  3. Dominic
  4. Jin Min
  5. Rachel
  6. Yun Zhen

What we discussed?

What other information and posts were lacking for our blog.

Our video content. Managed to settle the first video.

First video: Definition and Intro – What are drugs, how it is produced, different isomers

Tasks to be done before next meeting:

Think of video and script for 2nd video. Get the blog in order.

The meeting adjourned at 1600.

Meeting Log 3 (22nd March 2017)

Location: LT23

Time: 1500-1530

Duration: 30mins

Attendance

Present:

  1. Amanda
  2. Dominic
  3. Jin Min
  4. Rachel
  5. Yun Zhen

Absent:

  1.  Akshaya

What we discussed?

Our video content. We discussed what type and style of video we wanted.
First video: Definition and Intro – What are drugs, how it is produced, different isomers
Second video: Application – how it affects society, how we use it, advantages, disadvantages.

Tasks to be done before next meeting (29/3, 1230pm):

Think of video ideas. Add more content. Think of video script for both videos.

 

The meeting adjourned at 1530.

Application Exercise 7

  1. Styrofoam contains mostly air hence when it is released by dissolving it in acetone, it looks like the huge quantity of solid is dissolved into a smaller quantity of liquid and is more dense.

2a. LDPE is soft, stretchy and flexible. It will not be resistant to cuts.

2b. It is successful in this application as a thin layer of HDPE was used. This allows the gloves to be less rigid and more flexible. At the same time, HDPE is also orderly arranged, hence maintaining the strength and resistance to being cut.

3. This does not happen in paper. When the plastic is stretched, the 3D structure is altered whereby the molecules become aligned and move in the direction of the pull. This is because there are weak dispersion forces between the HDPE molecules and are easier to break.
On the contrary, paper tears when it is pulled. This is due to the cellulose molecules having stronger intermolecular forces of attraction between the molecules hence it is difficult for molecule to slip pass one another.

3a. It should be safe, biocompatible, cost effective and long lasting.

3b. Polymers such as polymethyl methacrylate (PMMA) are used. More commonly now is the use of Silicone-acrylate materials under trade names such as Kolfocon. Lenses that are comfortable, safe, inexpensive and permeable to oxygen are a few desirable properties.

3c. The difference is that in hard contact lenses, PMMA is used. It is a rigid non permeable plastic. In soft contact lenses, silicone is used. Silicone is more flexible and comfortable to the user during long hours of wear. Silicone also allows oxygen to reach the eye hence it is healthier and safer compared to PMMA.

Application Exercise 6

1a. Sulfate particles formed from sulfur dioxide which is produced by the coal fired plants. This results in the poor visibility.

1b. Normal rain is about pH5.3, since it is 10 times more acidic than natural, the rainfall in the park will have a pH of 4.3.

2a. By hanging it to dry, a dryer does not have to be used. This saves more electricity which is generated by burning of fossil fuels (in the US). With less burning of fossil fuels, less pollutants are produced and present in the atmosphere hence reducing acid rain.

2b. By taking public transport, less cars are used. This reduces emission of NOx and thus reduces the formation of acid rain.

2c. This is to save electricity as the machines will be used less frequently.  Electricity is generated by the burning of fossil fuels. With less burning of fossil fuels, less pollutants are produced and present in the atmosphere hence reducing acid rain.

2d. By insulating the pipes and heaters, we reduced the heat loss to environment. This decreases the amount of energy required to maintain the heat hence saving electricity by using fossil fuels. Burning of fossil fuels contribute to the formation of acid rain.

2e. By buying local food, our carbon footprint is reduced. This results in lesser pollutants formed and hence reduction of acid rain.

3a. Hydrochloric acid, HCl ; nitric acid, HNO3 ; sulfuric acid, H2SO4; carbonate acid, H2CO3 ; Phosphoric acid, H3PO4

sodium hydroxide, NaOH ; lithium hydroxide, LiOH ; magnesium hydroxide, Mg(OH)2; potassium hydroxide, KOH ; ammonia, NH3

3b. Acids are sour while bases are bitter. Acid turns blue litmus red while base turns red litmus blue. Both reacts with metals.

4. Some issues found in Singapore are the formation of acid rain and production of haze. Some examples are the corrosion of the National Museum of Singapore. Native species in Singapore including frogs, crabs and fishes may be wiped out by the acid rain. The haze is caused by the burning of biomass in neighbouring countries hence the acid deposition originates mostly from outside Singapore’s borders. Some acid deposition also originates from inside Singapore’s borders as pollutants are produced by automobiles and factories.

 

Generic Medicine

What Are Generic Drugs?

A generic drug is identical–or bioequivalent–to a brand name drug in dosage form, safety, strength, route of administration, quality, performance characteristics and intended use.  Although generic drugs are chemically identical to their branded counterparts, they are typically sold at substantial discounts from the branded price. According to the Congressional Budget Office, generic drugs save consumers an estimated $8 to $10 billion a year at retail pharmacies.  Even more billions are saved when hospitals use generics.

Drug companies must submit an abbreviated new drug application (ANDA) for approval to market a generic product.  The Drug Price Competition and Patent Term Restoration Act of 1984, more commonly known as the Hatch-Waxman Act, made ANDAs possible by creating a compromise in the drug industry. Generic drug companies gained greater access to the market for prescription drugs, and innovator companies gained restoration of patent life of their products lost during FDA’s approval process.

New drugs, like other new products, are developed under patent protection.  The patent protects the investment in the drug’s development by giving the company the sole right to sell the drug while the patent is in effect.  When patents or other periods of exclusivity expire, manufacturers can apply to the FDA to sell generic versions.  The ANDA process does not require the drug sponsor to repeat costly animal and clinical research on ingredients or dosage forms already approved for safety and effectiveness.  This applies to drugs first marketed after 1962.

Health professionals and consumers can be assured that FDA approved generic drugs have met the same rigid standards as the innovator drug. To gain FDA approval, a generic drug must:

  • contain the same active ingredients as the innovator drug(inactive ingredients may vary)
  • be identical in strength, dosage form, and route of administration
  • have the same use indications
  • be bioequivalent
  • meet the same batch requirements for identity, strength, purity, and quality
  • be manufactured under the same strict standards of FDA’s good manufacturing practice regulations required for innovator products

Meeting Log 2 (8th March 2017)

Location: LHS TR-08

Time: 1520-1600

Duration: 40mins

Attendance

Present:

  1. Akshaya
  2. Amanda
  3. Dominic
  4. Jin Min
  5. Rachel
  6. Yun Zhen

What we discussed?

Introduction – Akshaya and Dominic

How is it produced – Amanda

Advantages and disadvantages of medicine – Jin Min and Yun Zhen

Implications to Society – Rachel

 

Tasks to be done before next meeting (22/3):

Work on the blog. Gather more information from the web and chemistry textbooks as reference to put on the blog.

The meeting adjourned at 1600.